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ea0081ep751 | Pituitary and Neuroendocrinology | ECE2022

Immunohistochemichal expression of ephrin receptor (EPH)-A4, -A5, -B2 and -B5 in pituitary lesions

Papadimitriou Eirini , Kyriakopoulos Georgios , Barkas Konstantinos , Gkalonakis Ioannis , Pantoula Panagiota , Theocharis Stamatios , Kaltsas Gregory , Alexandraki Krystallenia

Introduction: Ephrin receptors (EPHs) compose the largest known subfamily of receptors tyrosine kinases and are bound and interact with EPHs-interacting proteins (Ephrins). They have a role in tumor growth, invasion, angiogenesis and metastasis of several neoplasms. Aim of the study was to investigate the expression of EPH-A4, -A5, -B2 and -B5 in pituitary lesions. Material and Methods: Our study group consisted of 18 patients (9 males with median age 54...

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ea0099ep244 | Pituitary and Neuroendocrinology | ECE2024

CTGF expression in human pituitary tumors and its association with their aggressiveness: preliminary data from an ongoing study

Vamvoukaki Rodanthi , Kyriakopoulos Georgios , Ntali Georgia , Vassiliadi Dimitra , Vlachou Panagiota , Koukoula Chrysoula , Barkas Konstantinos , Gkalonakis Ioannis , Tzanela Marinella , Andoniadou Cynthia , Xekouki Paraskevi

Background/Aim: Pituitary neuroendocrine tumors (PitNETs), although usually indolent, may display aggressive behavior. YAP/TAZ signalling has been linked to pituitary development and stem cell regulation, with a preliminary study from our group revealing elevated levels and nuclear localization of YAP/TAZ in non-functioning PitNETs (NF-PitNETs). CTGF, a YAP/TAZ target gene, encodes a secreted factor involved in proliferation and angiogenesis, that has been implicated ...

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Endocrine Abstracts

Immunohistochemichal expression of ephrin receptor (EPH)-A4, -A5, -B2 and -B5 in pituitary lesions

CTGF expression in human pituitary tumors and its association with their aggressiveness: preliminary data from an ongoing study

BiosciAbstracts